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首页> 外文OA文献 >Dynamic characteristics and adaptability of mouse vestibulo-ocular and optokinetic response eye movements and the role of the flocculo-olivary system revealed by chemical lesions
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Dynamic characteristics and adaptability of mouse vestibulo-ocular and optokinetic response eye movements and the role of the flocculo-olivary system revealed by chemical lesions

机译：小鼠前庭眼和视动反应眼动的动态特征和适应性以及化学损伤揭示的絮卵系统的作用

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The dynamic characteristics of reflex eye movements were measured in two strains of chronically prepared mice by using an infrared television camera system. The horizontal vestibulo-ocular reflex (HVOR) and horizontal optokinetic response (HOKR) were induced by sinusoidal oscillations of a turntable, in darkness, by 10° (peak to peak) at 0.11–0.50 Hz and of a checked-pattern screen, in light, by 5–20°at 0.11–0.17 Hz, respectively. The gains and phases of the HVOR and HOKR of the C57BL/6 mice were nearly equivalent to those of rabbits and rats, whereas the 129/Sv mice exhibited very low gains in the HVOR and moderate phase lags in the HOKR, suggesting an inherent sensory-motor anomaly. Adaptability of the HOKR was examined in C57BL/6 mice by sustained screen oscillation. When the screen was oscillated by 10° at 0.17 Hz, which induced sufficient retinal slips, the gain of the HOKR increased by 0.08 in 1 h on average, whereas the stimuli that induced relatively small or no retinal slips affected the gain very little. Lesions of the flocculi induced by local applications of 0.1% ibotenic acid and lesions of the inferior olivary nuclei induced by i.p. injection of 3-acetylpyridine in C57BL/6 mice little affected the dynamic characteristics of the HVOR and HOKR, but abolished the adaptation of the HOKR. These results indicate that the olivo-floccular system plays an essential role in the adaptive control of the ocular reflex in mice, as suggested in other animal species. The data presented provide the basis for analyzing the reflex eye movements of genetically engineered mice.
机译：通过使用红外电视摄像机系统，在两只长期准备的小鼠品系中测量了反射性眼球运动的动态特性。水平的前庭眼反射（HVOR）和水平的视动反应（HOKR）是由转盘的正弦振荡引起的，在黑暗中，在0.11–0.50 Hz处出现10°（峰-峰值），而在分别在0.11-0.17 Hz的频率下以5-20°的角度发光。 C57BL / 6小鼠的HVOR和HOKR的增益和相位几乎与兔和大鼠的相同，而129 / Sv小鼠的HVOR增益非常低，而HOKR的相位滞后适中，表明内在的感觉-运动异常。通过持续的屏幕振荡检查了C57BL / 6小鼠中HOKR的适应性。当屏幕以0.17 Hz的频率振动10°引起足够的视网膜滑动时，HOKR的增益平均在1小时内增加0.08，而引起相对较小或没有视网膜滑动的刺激对增益的影响很小。局部应用0.1％卵磷脂的诱导的絮状病变和经腹膜内注射诱导的下橄榄核的病变。在C57BL / 6小鼠体内注射3-乙酰基吡啶对HVOR和HOKR的动力学特性影响很小，但取消了HOKR的适应性。这些结果表明，如在其他动物物种中所建议的那样，卵小球系统在小鼠眼反射的适应性控制中起着至关重要的作用。所提供的数据为分析基因工程小鼠的反射眼运动提供了基础。

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